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Recombinant Human C-C motif chemokine 3-like 1 protein (CCL3L1) (Active)

Recombinant Human C-C motif chemokine 3-like 1 protein (CCL3L1) (Active)

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Code	CSB-AP000831HU
MSDS	MSDS
Size	$142
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Product Details
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Target Background

Product Details

Purity

>97% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU/μg as determined by LAL method.

Activity

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 1.0-10 ng/ml.

Target Names

CCL3L1

Uniprot No.

P16619

Research Area

Immunology

Alternative Names

464.2; C-C motif chemokine 3-like 1; CCL3L3; CL3L1_HUMAN; D17S1718; G0/G1 switch regulatory protein 19-2; G0S19-2; LD78; LD78-beta(1-70); LD78-beta(5-70); LD78BETA; PAT 464.2; SCYA3L; SCYA3L1; Small-inducible cytokine A3-like 1; Tonsillar lymphocyte LD78 beta protein

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

24-93aa

Complete Sequence

APLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPSV IFLTKRGRQV CADPSEEWVQ KYVSDLELSA

Mol. Weight

7.8 kDa

Protein Length

Full Length of Mature Protein

Tag Info

Tag-Free

Form

Lyophilized powder

Buffer

Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

5-10 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

The Recombinant Human CCL3L1 protein is an essential research tool for investigators focusing on immunology. This C-C motif chemokine 3-like 1 protein, also known by its aliases CCL3L1, CCL3L3, D17S1718, G0S19-2, and SCYA3L1, is expressed in E. coli and covers the 24-93aa region, encompassing the full length of the mature protein. This tag-free, lyophilized powder can be readily reconstituted with sterile water or an appropriate buffer to accommodate various experimental needs.

Our Recombinant Human CCL3L1 protein exhibits a high purity of >97%, as established by both SDS-PAGE and HPLC analyses. The endotoxin levels are stringently controlled, ensuring they remain below 1.0 EU/µg, as verified by the LAL method. The protein is fully biologically active when compared to standard, with its biological activity determined by a chemotaxis bioassay using human monocytes within a concentration range of 1.0-10 ng/ml.

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Target Background

Function

Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.

Gene References into Functions

severe periodontal tissue destruction in Papillon-Lefevre syndrome may be related to excess accumulation of LD78beta and LD78alpha and dysregulation of the microbial-induced inflammatory response in the periodontium PMID: 15728180

Subcellular Location

Secreted.

Protein Families

Intercrine beta (chemokine CC) family

Database Links

HGNC: 10628

OMIM: 601395

KEGG: hsa:414062

STRING: 9606.ENSP00000408984

UniGene: Hs.454713

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